Peer-reviewed veterinary case report
Salinomycin with doxorubicin lowers cat sarcoma and carcinoma cell
By Borlle, Lucia et al.·Published in BMC veterinary research·2019·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Salinomycin decreases feline sarcoma and carcinoma cell viability when combined with doxorubicin.
- Species:
- cat
Plain-English summary
A study found that salinomycin, when combined with the chemotherapy drug doxorubicin, may help treat certain types of cancer in cats, specifically sarcomas. Researchers tested this combination on two new types of feline cancer cells and discovered that it significantly reduced the viability of these cancer cells more effectively than either drug alone. This suggests that salinomycin could enhance the effectiveness of doxorubicin in treating feline cancers. However, more research is needed to understand how salinomycin works and its safety for healthy cat tissues.
People also search for: cat cancer treatment options · doxorubicin for feline sarcoma · salinomycin effects on cat tumors
Abstract
BACKGROUND: Cancer is a significant health threat in cats. Chemoresistance is prevalent in solid tumors. The ionophore salinomycin has anti-cancer properties and may work synergistically with chemotherapeutics. The purpose of our study was to determine if salinomycin could decrease cancer cell viability when combined with doxorubicin in feline sarcoma and carcinoma cells. RESULTS: We established two new feline injection-site sarcoma cell lines, B4 and C10, and confirmed their tumorigenic potential in athymic nude mice. B4 was more resistant to doxorubicin than C10. Dose-dependent effects were not observed until 92 μM in B4 cells (p = 0.0006) vs. 9.2 μM (p = 0.0004) in C10 cells. Dose-dependent effects of salinomycin were observed at 15 μM in B4 cells (p = 0.025) and at 10 μM in C10 cells (p = 0.020). Doxorubicin plus 5 μM salinomycin decreased viability of B4 cells compared to either agent alone, but only at supra-pharmacological doxorubicin concentrations. However, doxorubicin plus 5 μM salinomycin decreased viability of C10 cells compared to either agent alone at doxorubicin concentrations that can be achieved in vivo (1.84 and 4.6 μM, p < 0.004). In SCCF1 cells, dose-dependent effects of doxorubicin and salinomycin were observed at 9.2 (p = 0.036) and 2.5 (p = 0.0049) μM, respectively. When doxorubicin was combined with either 1, 2.5, or 5 μM of salinomycin in SCCF1 cells, dose-dependent effects of doxorubicin were observed at 9.2 (p = 0.0021), 4.6 (p = 0.0042), and 1.84 (p = 0.0021) μM, respectively. Combination index calculations for doxorubicin plus 2.5 and 5 μM salinomycin in SCCF1 cells were 0.4 and 0.6, respectively. CONCLUSIONS: We have developed two new feline sarcoma cell lines that can be used to study chemoresistance. We observed that salinomycin may potentiate (C10 cells) or work synergistically (SCCF1 cells) with doxorubicin in certain feline cancer cells. Further research is indicated to understand the mechanism of action of salinomycin in feline cancer cells as well as potential tolerability and toxicity in normal feline tissues.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30678671/