Peer-reviewed veterinary case report
How sarcoptic mange affects liver and vitamins in dogs
By Beigh, S A et al.·Published in Veterinary parasitology·2016·Department of Clinical Veterinary Medicine, India·View original on PubMed →
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Original publication title: Sarcoptic mange in dogs: Its effect on liver, oxidative stress, trace minerals and vitamins.
- Species:
- dog
Plain-English summary
A group of dogs with sarcoptic mange, a skin condition caused by mites, showed significant health issues related to their liver and overall well-being. The study found that dogs with severe infestations had lower levels of important blood components and vitamins, along with increased liver enzymes, indicating liver stress. These dogs also had higher oxidative stress levels, which can damage cells. Treatment for sarcoptic mange typically involves medications to kill the mites, and addressing any nutritional deficiencies can help improve the dogs' health.
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Abstract
The present study was aimed to determine the effect on liver, associated oxidative stress, trace element and vitamin alteration in dogs with sarcoptic mange. A total of 24 dogs with clinically established diagnosis of sarcoptic mange, divided into two groups, severely infested group (n=9) and mild/moderately infested group (n=15), according to the extent of skin lesions caused by sarcoptic mange and 6 dogs as control group were included in the present study. In comparison to healthy control hemoglobin, PCV, and TEC were significantly (P<0.05) decreased in dogs with sarcoptic mange however, significant increase in TLC along with neutrophilia and lymphopenia was observed only in severely infested dogs. The albumin, glucose and cholesterol were significantly (P<0.05) decreased and globulin, ALT, AST and bilirubin were significantly (P<0.05) increased in severely infested dogs when compared to other two groups. Malondialdehyde (MDA) levels were significantly (P<0.01) higher in dogs with sarcoptic mange, with levels highest in severely infested groups. Activity of superoxide dismutase (SOD) (P<0.05) and catalase were significantly (P<0.01) lower in sarcoptic infested dogs when compared with the healthy control group. Zinc and copper levels in dogs with sarcoptic mange were significantly (P<0.05) lower when compared with healthy control group with the levels lowest in severely infested group. Vitamin A and vitamin C levels were significantly (P<0.05) lower in sarcoptic infested dogs when compared to healthy control. From the present study, it was concluded that sarcoptic mange in dogs affects the liver and the infestation is associated with oxidant/anti-oxidant imbalance, significant alteration in trace elements and vitamins.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27523934/