Peer-reviewed veterinary case report
Dog with sellar brain mass causing weakness and seizures
By Cramer, Sarah D et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2011·Oklahoma State University, United States·View original on PubMed →
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Original publication title: Sellar xanthogranuloma in a dog.
- Species:
- dog
Plain-English summary
A 7-year-old male standard Poodle with a history of thyroid and adrenal gland issues suddenly became very lethargic, weak, and stopped eating. He also experienced vomiting, diarrhea, and showed signs of confusion and aggressive behavior, along with a possible seizure. Unfortunately, after he passed away, a necropsy revealed a mass in his brain that resembled a type of inflammatory growth known as xanthogranuloma. This condition is similar to what can occur in humans and may have contributed to his severe symptoms.
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Abstract
A 7-year-old, intact male standard Poodle dog with hypothyroidism and atypical hyperadrenocorticism developed acute signs of lethargy, weakness, inappetence, vomiting, and diarrhea. Clinical signs progressed to hind limb proprioceptive deficits, aggressive behavior with obtundation, and an equivocal seizure. Necropsy revealed a mass in the sellar region that histologically consisted of multinucleated giant cells, macrophages, and hemosiderin-laden macrophages with fewer lymphocytes and plasma cells admixed with large regions of cholesterol cleft deposition, fibrin, and prominent Rosenthal fibers. Pituitary tissue was not identified on gross or histologic examination, but the mass was partially bordered by epithelial cells. The histologic characteristics are similar to changes described in the human medical literature as xanthogranuloma of the sellar region and xanthogranulomatous hypophysitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21398471/