Peer-reviewed veterinary case report
Detecting canine alimentary lymphoma with biopsy gene test sensitivity
By Fukushima, Kenjiro et al.·Published in The Journal of veterinary medical science·2009·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Sensitivity for the detection of a clonally rearranged antigen receptor gene in endoscopically obtained biopsy specimens from canine alimentary lymphoma.
- Species:
- dog
Plain-English summary
A group of 12 dogs with suspected intestinal lymphoma underwent endoscopic biopsies to confirm the diagnosis. While traditional tests can struggle to differentiate between lymphoma and other conditions like lymphocytic-plasmacytic enteritis, a new test called PARR (polymerase chain reaction for antigen receptor gene rearrangement) was used. This test was able to correctly identify lymphoma in about 67% of cases, which is lower than for other types of lymphoid cancers. Combining PARR with standard histopathological examination may help vets make more accurate diagnoses for dogs with this condition.
People also search for: dog intestinal lymphoma diagnosis · PARR test for dogs · canine lymphoma symptoms
Abstract
Canine alimentary lymphoma is currently diagnosed on the basis of findings of cytological or histopathological examination. However, it is often difficult to histopathologically distinguish alimentary lymphoma from lymphocytic-plasmacytic enteritis. Recently, the application of polymerase chain reaction for antigen receptor gene rearrangement (PARR) has been reported. In the present study, we assess the sensitivity of PARR analysis in diagnosing canine alimentary lymphoma using endoscopically obtained biopsy specimens from 12 dogs that were histopathologically diagnosed as having lymphoma. The sensitivity of PARR analysis in diagnosing alimentary lymphoma was found to be 66.7%, which was lower than that of other lymphoid malignancies. A combination of histipathological examination and findings of PARR analysis may improve the diagnostic accuracy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20046040/