Peer-reviewed veterinary case report
Blood clotting changes over time in dogs with immune-mediated anemia
By Goggs, R et al.·Published in Veterinary journal (London, England : 1997)·2012·Royal Veterinary College, United Kingdom·View original on PubMed →
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Original publication title: Serial assessment of the coagulation status of dogs with immune-mediated haemolytic anaemia using thromboelastography.
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with immune-mediated hemolytic anemia (IMHA) were monitored over five days to assess their blood clotting ability. The tests showed that most dogs had an increased tendency to form clots, which could be a concern. Interestingly, dogs that had better clotting measurements at the start were more likely to survive for at least 30 days. Overall, about 80% of the dogs survived this period, and those with higher clotting scores had a better chance of recovery.
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Abstract
This study investigated the coagulation status of dogs with immune-mediated haemolytic anaemia (IMHA) over time. Thirty animals with primary IMHA were blood sampled on three occasions over a 5 day period and assays performed included prothrombin time, activated partial thromboplastin time, D-dimer and fibrinogen concentration, antithrombin activity and recalcified unactivated thromboelastography (TEG). Based on TEG, dogs with IMHA were significantly hypercoagulable vs. controls (P<0.001) and over the 5 day period, 3/4 of the TEG parameters reflected increased clotting kinetics (P ≤ 0.02). The 30 day survival of these patients was 80% and, at hospital admission, the TEG maximum amplitude (MA) was significantly higher in survivors than non-survivors (P=0.015). Each unit increase in MA was associated with an increased odds of 30 day survival of 1.13 (95%; CI 1.02-1.25). Based on TEG, most dogs with IMHA were hypercoagulable on admission and their clotting kinetics increased with time. Relative hypocoagulability identified by TEG at initial assessment was found to be a negative prognostic indicator.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21514858/