Peer-reviewed veterinary case report
Heart injury marker levels linked to survival in dogs with parvovirus
By Oikonomidis, I L et al.·Published in Research in veterinary science·2023·School of Veterinary Medicine·View original on PubMed →
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Original publication title: Serial measurement of cardiac troponin I in hospitalised dogs with canine parvoviral enteritis: Association with outcome and canine pancreas-specific lipase concentration.
- Species:
- dog
Plain-English summary
A group of dogs hospitalized for parvoviral enteritis (a serious intestinal infection) had their heart protein levels measured over five days to see how it related to their recovery. Out of 29 dogs, those that did not survive had higher levels of cardiac troponin I (cTnI) by day five compared to those that did recover. Interestingly, while some dogs showed signs of pancreatitis, the heart protein levels did not correlate with those findings. This suggests that monitoring cTnI can help predict outcomes in dogs with this condition, but it doesn't indicate issues with the pancreas.
People also search for: dog parvovirus treatment · dog heart problems symptoms · pancreatitis in dogs signs
Abstract
The aim of this study was to serially evaluate serum cardiac troponin I (cTnI) concentrations in dogs with parvoviral enteritis (CPVE), and investigate the association with outcome and serum pancreas-specific lipase (Spec cPL) concentrations. Dogs with CPVE that were hospitalised for at least 5 days were included. cTnI and Spec cPL concentrations were measured on days 1, 3 and 5 of hospitalisation. Twenty-nine dogs (20 survivors, 9 non-survivors) were included. Spec cPL was indicative of pancreatitis (>400 μg/L) on at least one day in 10/29 (34.5%) dogs. Serum median (range) cTnI concentration was higher (P = 0.021) in non-survivors on day 5 [0.032 (0.001-0.395) ng/mL] compared to day 1 [0.012 (0.003-0.196) ng/mL]. Non-survivors had higher (P = 0.014) cTnI concentrations on day 5 [0.032 (0.001-0.395) ng/mL] compared to survivors [0.001 (0.001-0.042) ng/mL], but not at admission or on day 3 (P > 0.05). Serum cTnI concentrations were not significantly different (P = 0.465) between the three Spec cPL groups [group 1 (Spec cPL ≤ 200 μg/L): 0.007 (0.001-0.527) ng/mL; group 2 (Spec cPL: 201-399 μg/L): 0.0045 (0.001-0.196) ng/mL; group 3 (Spec cPL ≥ 400 μg/L): 0.011 (0.001-0.278) ng/mL]. cTnI and Spec cPL concentrations were not significantly correlated (rho = -0.043, P = 0.703). Serial measurement of cTnI had prognostic value in the examined cohort. However, cTnI was not correlated with spec cPL.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36827790/