Peer-reviewed veterinary case report
Puppy immune response to modified-live canine parvovirus vaccine
By O’Brien, Susan E.·Published in Journal of the American Veterinary Medical Association·1994·From the Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, Iowa State University, Ames, IA 50011.·View original on Crossref →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Serologic response of pups to the low-passage, modified-live canine parvovirus-2 component in a combination vaccine
- Species:
- dog
Plain-English summary
Thirty puppies were vaccinated against canine parvovirus-2 (cpv-2) every three weeks until they were between 11 and 18 weeks old. Most of the puppies developed protective antibody levels after just one or two doses of the vaccine, even those who initially had low or no antibodies. The study suggests that puppies at high risk for cpv-2 should continue to be vaccinated until they are 18 to 20 weeks old, while those at lower risk can be vaccinated until they are 16 weeks old. This vaccination strategy helps ensure that puppies are protected from this serious disease.
People also search for: puppy parvovirus vaccine schedule · how often should puppies be vaccinated · canine parvovirus symptoms in puppies
Abstract
Summary Thirty pups from a general pet population were vaccinated for canine parvovirus-2 (cpv-2), using a low-passage, modified-live cpv-2 in a combination vaccine, every 3 weeks until the pups were between 11 and 18 weeks old. Canine parvovirus-2 antibody titers were measured by means of serum neutralization (sn) immediately before each vaccination and ≥ 2 weeks after final vaccination. Thirteen pups that were initially seronegative (sn titer < 2 for cpv-2) developed protective titers (sn titer ≥ 16) after 1 to 3 doses of the vaccine, administered when the pups were between 8 and 17 weeks old; 11 of the 13 developed protective titers after the first dose. Seventeen pups were initially seropositive for cpv-2 (sn titer ≥ 2). Of these, 8 initially had titers < 16 and 3 others had titers that fell to < 16 during the study. Nine (82%) of these 11 pups developed protective titers. Results indicated that pups at high risk for cpv-2 disease should be vaccinated until 18 to 20 weeks old, even when the low-passage vaccine is used. Pups at lower risk of cpv-2 disease should be vaccinated periodically until 16 weeks old.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on Crossref: https://doi.org/10.2460/javma.1994.204.08.1207