Peer-reviewed veterinary case report
Vitamin D levels in dogs linked to health and cancer risk
By Selting, K. A. et al.·Published in Veterinary and Comparative Oncology·2014·Veterinary Medical Teaching Hospital University of Missouri Columbia MO USA, United States·View original on Crossref →
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Original publication title: Serum 25‐hydroxyvitamin D concentrations in dogs – correlation with health and cancer risk
- Species:
- dog
Plain-English summary
A study found that dogs with low levels of vitamin D (25-hydroxyvitamin D) may have a higher risk of developing cancer. In healthy dogs, those with adequate vitamin D levels showed better overall health, while dogs with a condition called haemoabdomen (bleeding in the abdomen) had varying vitamin D levels, with lower levels linked to malignant tumors. The research suggests that measuring vitamin D levels in dogs can help identify those who might benefit from vitamin D supplements, potentially improving their health and response to cancer treatments.
People also search for: dog cancer risk vitamin D · dog haemoabdomen treatment · how to increase vitamin D in dogs
Abstract
Abstract25‐hydroxyvitamin D (25(OH)D) is important in bone health as well as many diseases including cancer. Supplementation may increase responsiveness of cancer cells to chemotherapy. Serum 25(OH)D, intact parathyroid hormone (iPTH) and canine C‐reactive protein (c‐CRP) were measured in healthy dogs and dogs with haemoabdomen. Regression analysis determined optimal 25(OH)D concentrations. In healthy dogs (n = 282), mean iPTH concentrations correlated inversely (r2 = 0.88, P < 0.001) to 25(OH)D concentrations. Variation in both iPTH and c‐CRP plateaued at 25(OH)D concentrations of 100–120 ng mL−1. Haemoabdomen dogs (n = 63, 43 malignant and 20 benign) had 25(OH)D concentrations ranging from 19.4 to >150 ng mL−1. Relative risk of cancer increased with decreasing 25(OH)D concentrations [RR = 3.9 for 25(OH)D below 40 ng mL−1 (P = 0.0001)]. Serum 25(OH)D concentrations in dogs vary widely, and are influenced by dietary VitD content. Serum vitD measurement can identify dogs for which supplementation may improve health and response to cancer therapy.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vco.12101