Peer-reviewed veterinary case report
Serum amyloid A levels in cats with gastrointestinal lymphoma
By Akiyoshi, Makoto et al.·Published in The Journal of veterinary medical science·2023·Azabu University, Japan·View original on PubMed →
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Original publication title: Serum amyloid A (SAA) concentration in cats with gastrointestinal lymphoma.
- Species:
- cat
Plain-English summary
A group of 39 cats diagnosed with gastrointestinal lymphoma (a type of cancer affecting the digestive system) had their blood tested for a protein called serum amyloid A (SAA), which can indicate disease severity. The cats were divided into two groups based on the aggressiveness of their lymphoma: high-grade and low-grade. It was found that cats with low-grade lymphoma had higher SAA levels at the start, while elevated SAA levels in high-grade lymphoma were linked to a worse outcome over time. Monitoring SAA levels could help veterinarians predict how well a cat with gastrointestinal lymphoma might respond to treatment.
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Abstract
The incidence of feline gastrointestinal (GI) lymphoma has recently increased. Serum amyloid A (SAA) levels are elevated in feline lymphoma. However, no reports have evaluated SAA concentrations and outcomes in feline GI lymphoma. This study aimed to evaluate the clinical utility of SAA and other factors in feline GI lymphoma to assess the outcomes with potential differences. The study included 39 client-owned cats diagnosed with GI lymphoma, which were divided into two groups: high- and low-grade lymphomas. Changes in SAA concentration, complete blood count (CBC), and biochemical profiles were analyzed at the time of initial presentation as well as on days 1, 28, and 56. Differences between the two groups were investigated. High-grade lymphoma was observed in 17 cats, whereas 22 cats showed low-grade lymphoma. SAA concentrations on the day of initial presentation were significantly higher in low-grade lymphoma than those in high-grade lymphoma (median, 12.4 µg/mL; range, 4.8-46.5 µg/mL vs. 3.8 µg/mL; 3.8-13.7 µg/mL; P=0.011). Elevated SAA concentration on day 56 in high-grade GI lymphoma was a poor prognostic factor. (Hazard Ratio=1.012, per 1 µg/mL increase; 95% confidence interval; 1.004-1.020, P=0.002). The SAA concentration on the day of initial presentation did not serve as a suitable prognostic factor and did not depend on the grade or stage of the lymphoma. However, continuous SAA concentration measurement may be useful for predicting the outcome of feline GI lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37357392/