Peer-reviewed veterinary case report
Antioxidant levels and damage in dogs with ehrlichiosis infection
By Rubio, Camila Peres et al.·Published in Research in veterinary science·2017·Department of Animal Medicine and Surgery, Spain·View original on PubMed →
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Original publication title: Serum antioxidant capacity and oxidative damage in clinical and subclinical canine ehrlichiosis.
- Species:
- dog
Plain-English summary
A group of dogs with ehrlichiosis, a tick-borne disease, showed signs of oxidative stress, which means their bodies were struggling to fight off damage from free radicals. The study found that dogs with clinical ehrlichiosis had lower levels of antioxidants in their blood compared to healthy dogs, indicating their bodies were under more stress. Even dogs with subclinical ehrlichiosis (showing no obvious symptoms) had some reduced antioxidant levels. While some tests showed no significant differences in oxidative damage between sick and healthy dogs, the overall findings suggest that ehrlichiosis affects the dogs' ability to manage oxidative stress. Treatment for ehrlichiosis typically involves antibiotics, which can help improve their condition.
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Abstract
The objective of this study was to evaluate and compare the antioxidant response and the products of oxidative damage analysed by various assays in clinical and subclinical canine monocytic ehrlichiosis (CME). For this purpose, four assays to measure the total serum antioxidant capacity (TAC), such as the cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of plasma (FRAP), trolox equivalent antioxidant capacity (TEAC) using acidic medium (TEAC), and the TEAC using the horseradish peroxidase (TEAC) were used. In addition, the serum thiol concentrations were analysed. Reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), and ferrous oxidation-xylenol orange (FOX) were measured to determine the concentrations of free radical and the products of oxidative damage as result of the disease. All antioxidant markers were significantly lower in the dogs on clinical ehrlichiosis when compared with healthy dogs; however only the CUPRAC, FRAP and thiol were significantly lower in subclinical CME compared with healthy dogs. TBARS and FOX showed no significant differences between dogs with CME and healthy dogs; however, a significant increased ROS concentration was observed in dogs with clinical and subclinical CME when compared with healthy dogs. Results showed that in CME there is a state of oxidative stress with significant changes in markers of antioxidant defence and in concentrations of free radicals. However, the detection of these changes would depend of the assay used.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28628845/