Peer-reviewed veterinary case report
C-reactive protein blood test helps diagnose bacterial respiratory
By Viitanen, S J et al.Ā·Published in Journal of veterinary internal medicineĀ·2014Ā·Department of Equine and Small Animal MedicineĀ·View original on PubMed ā
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Original publication title: Serum C-reactive protein as a diagnostic biomarker in dogs with bacterial respiratory diseases.
- Species:
- dog
Plain-English summary
A group of dogs with various respiratory issues, including bacterial pneumonia, were tested for levels of C-reactive protein (CRP), which can indicate inflammation. The study found that dogs with bacterial pneumonia had much higher CRP levels compared to those with other respiratory conditions or healthy dogs. This suggests that measuring CRP could help veterinarians diagnose bacterial pneumonia more effectively. The findings indicate that CRP might be a useful tool in identifying serious respiratory diseases in dogs.
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Abstract
BACKGROUND: C-reactive protein (CRP) is a major acute-phase protein in dogs. Serum concentrations are low in healthy animals, but increase rapidly after inflammatory stimuli. OBJECTIVE: The aim of the study was to investigate CRP concentrations in various respiratory diseases of dogs and to determine if CRP can be used as a biomarker in the diagnosis of bacterial respiratory diseases. ANIMALS: A total of 106 privately owned dogs with respiratory diseases (17 with bacterial tracheobronchitis [BTB], 20 with chronic bronchitis [CB], 20 with eosinophilic bronchopneumopathy [EBP], 12 with canine idiopathic pulmonary fibrosis [CIPF], 15 with cardiogenic pulmonary edema [CPE], and 22 with bacterial pneumonia [BP]) and 72 healthy controls. METHODS: The study was conducted as a prospective cross-sectional observational study. CRP was measured in serum samples. Diagnosis was confirmed by clinical and laboratory findings, diagnostic imaging, and selected diagnostic methods such as cytological and microbiological analysis of respiratory samples, echocardiography, and histopathology. RESULTS: Dogs with BP had significantly higher CRP concentrations (median, 121 mg/L; interquartile range, 68-178 mg/L) than dogs with BTB (23, 15-38, P = .0003), CB (13, 8-14, P < .0001), EBP (5, 5-15, P < .0001), CIPF (17, 10-20, P < .0001), or CPE (19, 13-32, P < .0001) and healthy controls (14, 8-20, P < .0001). Dogs with BTB had significantly higher CRP concentrations than dogs with CB (P = .001) or EBP (P < .0001) and healthy controls (P = .029). CONCLUSION AND CLINICAL IMPORTANCE: These results indicate that CRP has potential for use as an additional biomarker, especially in the diagnostics of BP.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24351049/