Peer-reviewed veterinary case report
HDL cholesterol levels drop and recover after treatment in dogs
By Ibba, Fabrizio et al.·Published in Research in veterinary science·2015·Department of Veterinary Sciences and Public Health, Italy·View original on PubMed →
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Original publication title: Serum concentration of high density lipoproteins (HDLs) in leishmaniotic dogs.
- Species:
- dog
Plain-English summary
Ten dogs with leishmaniasis (a disease caused by parasites) had their blood tested to see how their cholesterol levels and antioxidant activity changed before and after treatment. The dogs had low levels of good cholesterol (HDL) and an important enzyme (PON-1) when they first came in, but these levels increased after they were treated with medications. The study found that higher HDL levels were linked to lower inflammation markers, suggesting that monitoring HDL levels could help track how well dogs are responding to treatment for leishmaniasis.
People also search for: dog leishmaniasis treatment · low HDL cholesterol in dogs · monitoring inflammation in dogs
Abstract
In order to assess whether the concentration of high density lipoproteins (HDLs) changes in leishmaniotic dogs before and after treatment, HDL cholesterol (HDL-Chol and HDL%), C reactive protein (CRP) and activity of the antioxidant enzyme paraoxonase (PON-1) were measured in sera from 10 controls and 10 leishmaniotic dogs. Seven of these latter were sampled also 3, 7, 14, 21 and 28 days after treatment with antimonials and allopurinol. HDL-chol, and PON-1 were low in leishmaniotic dogs at admission and increased after treatment. HDL-chol and HDL% correlated positively with PON-1 and negatively with CRP suggesting that HDLs decrease through an oxidative mechanism. Therefore, HDLs may be used to monitor the magnitude of oxidation associated with inflammation in leishmaniotic dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25440996/