Peer-reviewed veterinary case report
High serum cystatin C levels predict kidney disease risk in small dogs
By Iwasa, Naoki et al.·Published in Research in veterinary science·2018·Hashima Animal Hospital, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Serum cystatin C concentration measured routinely is a prognostic marker for renal disease in dogs.
- Species:
- dog
Plain-English summary
A group of small dogs weighing less than 15 kg had their blood tested for a substance called cystatin C during regular check-ups to see if it could predict kidney problems. The results showed that dogs with higher levels of cystatin C were more likely to develop serious kidney disease and had a shorter survival time compared to those with lower levels. Specifically, dogs with cystatin C levels above 0.55 mg/dl faced a worse prognosis. This finding suggests that measuring cystatin C during routine exams could help veterinarians identify dogs at risk for kidney disease earlier.
People also search for: dog kidney disease symptoms · cystatin C test for dogs · small dog kidney health monitoring
Abstract
This study examined the predictive value of serum cystatin C (Cys-C) concentration, measured during routine periodic health examinations, in the renal prognosis of dogs. A cohort of 140 dogs weighing <15 kg whose serum Cys-C concentrations were measured during periodic health examinations from December 2013 to March 2016 were prospectively studied, with renal disease-related death the predicted end point. Of the 140 dogs, nine died from renal diseases during the follow-up period (539 ± 249 days). Serum Cys-C concentrations were higher in the dogs that subsequently died of renal disease than in the censored group (0.8 ± 0.25 vs. 0.3 ± 0.1 mg/dl, respectively; P < .01). Dogs with high serum Cys-C concentrations (>0.55 mg/dl) had a shorter (P < .01) renal disease-specific survival period than those with low serum Cys-C concentrations (≤0.55 mg/dl). In conclusion, high serum Cys-C concentrations in periodic health examinations in dogs <15 kg predicted poorer prognosis for renal function.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29913326/