Peer-reviewed veterinary case report
Blood ferritin rises and paraoxonase-1 falls in dogs
By Martinez-Subiela, S et al.·Published in Comparative immunology, microbiology and infectious diseases·2014·University of Murcia, Spain·View original on PubMed →
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Original publication title: Serum ferritin and paraoxonase-1 in canine leishmaniosis.
- Species:
- dog
Plain-English summary
A group of dogs infected with Leishmania (a parasite that can cause serious health issues) showed changes in their blood levels of ferritin and paraoxonase-1 (PON-1), which are indicators of inflammation and liver function. After being treated with allopurinol for three months, these levels returned to normal over the following months. Dogs with more severe kidney issues, indicated by higher protein levels in their urine, had significantly higher ferritin levels and lower PON-1 activity. This suggests that monitoring these blood markers can help assess the severity of the disease and the effectiveness of treatment.
People also search for: dog leishmaniasis treatment · elevated ferritin in dogs · dog kidney disease symptoms
Abstract
Ferritin and paraoxonase-1 (PON-1) were measured in dogs experimentally infected by Leishmania infantum (during experimental infection and following treatment) and also in naturally-infected dogs which presented different degrees of proteinuria. Experimentally-infected dogs were monitored for 7 months post-infection, then treated for 3 months with allopurinol, and their response to therapy was followed for 11 additional months. Naturally-infected dogs were staged based on the urine protein/creatinine (UPC) ratio into three groups as follows: group 1 (non-proteinuric; UPC ratio: <0.2), group 2 (borderline proteinuric; UPC ratio: 0.2-0.5) and group 3 (proteinuric; UPC ratio>0.5). An increase in serum ferritin values and a decrease in PON-1 activity were observed 2 months after infection. Both analytes returned to preinfection values following treatment. Significantly higher concentrations of ferritin were observed in dogs classified as either borderline or proteinuric when compared with non-proteinuric dogs whereas serum PON-1 activity was decreased only in proteinuric dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24268430/