Peer-reviewed veterinary case report
Blood protein patterns in cats with chronic gut disease
By Yu, Jane et al.Ā·Published in Journal of veterinary internal medicineĀ·2023Ā·Sydney School of Veterinary Science, United KingdomĀ·View original on PubMed ā
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Original publication title: Serum proteome profiles in cats with chronic enteropathies.
- Species:
- cat
Plain-English summary
A group of ten cats with gastrointestinal problems lasting at least three weeks were studied to find out if certain proteins in their blood could help diagnose chronic enteropathies (CE), which are long-term gut issues. Researchers found that one protein, thrombospondin-1, was significantly higher in cats with CE compared to healthy cats. This suggests that measuring this protein could help veterinarians identify and monitor gut inflammation in cats. While this study is preliminary, it points to a promising new way to diagnose and manage chronic gut issues in our feline friends.
People also search for: cat gastrointestinal problems Ā· chronic enteropathy in cats Ā· cat blood test for gut issues
Abstract
BACKGROUND: Serum protein biomarkers are used to diagnose, monitor treatment response, and to differentiate various forms of chronic enteropathies (CE) in humans. The utility of liquid biopsy proteomic approaches has not been examined in cats. HYPOTHESIS/OBJECTIVES: To explore the serum proteome in cats to identify markers differentiating healthy cats from cats with CE. ANIMALS: Ten cats with CE with signs of gastrointestinal disease of at least 3 weeks duration, and biopsy-confirmed diagnoses, with or without treatment and 19 healthy cats were included. METHODS: Cross-sectional, multicenter, exploratory study with cases recruited from 3 veterinary hospitals between May 2019 and November 2020. Serum samples were analyzed and evaluated using mass spectrometry-based proteomic techniques. RESULTS: Twenty-six proteins were significantly (P < .02, ≥5-fold change in abundance) differentially expressed between cats with CE and controls. Thrombospondin-1 (THBS1) was identified with >50-fold increase in abundance in cats with CE (P < 0.001) compared to healthy cats. CONCLUSIONS AND CLINICAL IMPORTANCE: Damage to the gut lining released marker proteins of chronic inflammation that were detectable in serum samples of cats. This early-stage exploratory study strongly supports THBS1 as a candidate biomarker for chronic inflammatory enteropathy in cats.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37279179/