Peer-reviewed veterinary case report
Serum uromodulin levels in dogs with chronic kidney disease
By Seo, Dansong et al.·Published in Journal of veterinary internal medicine·2022·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Serum uromodulin in dogs with chronic kidney disease.
- Species:
- dog
Plain-English summary
A group of dogs with chronic kidney disease (CKD) had lower levels of a substance called serum uromodulin compared to healthy dogs. This study found that measuring serum uromodulin could help veterinarians diagnose CKD more accurately, especially in its early stages. The results suggest that serum uromodulin is a promising new marker for identifying kidney issues in dogs. If your dog is showing signs of kidney problems, discussing this test with your veterinarian could be beneficial.
People also search for: dog kidney disease symptoms · chronic kidney disease in dogs · serum uromodulin test for dogs
Abstract
BACKGROUND: Serum uromodulin concentration has been described as a novel biomarker of chronic kidney disease (CKD) in humans but not dogs. OBJECTIVE: To evaluate the serum uromodulin concentration in dogs with CKD and assess its diagnostic performance in distinguishing dogs with CKD from healthy dogs. ANIMALS: Forty-nine dogs with CKD (International Renal Interest Society [IRIS] Stage 1, n = 23; Stage 2, n = 20; Stage 3-4, n = 6) and 25 healthy controls. METHODS: Prospective, observational study. Serum uromodulin concentration was measured using a canine-specific enzyme-linked immunosorbent assay (ELISA), and its correlation with conventional renal markers was analyzed. RESULTS: Serum uromodulin concentrations were significantly lower in the CKD group than in the control group (P < .001), but no significant difference was observed among stages of CKD. A negative correlation was observed between serum uromodulin concentration and conventional renal markers (blood urea nitrogen concentration, r = -.60, P < .0001; serum creatinine concentration, r = -.46, P < .0001; serum symmetric dimethylarginine concentration [SDMA], r = -.65, P < .0001). In receiver operating characteristic analysis, the area under the curve (AUC) of uromodulin (AUC, 0.97; 95% confidence interval [CI], 0.94-1.00) was higher than that of SDMA (AUC, 0.87; 95% CI, 0.79-0.95) for CKD diagnosis (P = .01). The AUC of uromodulin (AUC, 0.95; 95% CI, 0.89-1.00) also was higher than that of SDMA (AUC, 0.72; 95% CI, 0.58-0.87) in distinguishing dogs with Stage 1 CKD from controls (P = .001). CONCLUSIONS AND CLINICAL IMPORTANCE: Serum uromodulin concentration is decreased in dogs with CKD. Thus, serum uromodulin may be a valuable diagnostic marker for CKD in dogs, particularly in identifying early-stage CKD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36330885/