Peer-reviewed veterinary case report
Low serum alpha-proteinase inhibitor in dogs with proteinuric kidney
By Heilmann, R M et al.·Published in Veterinary journal (London, England : 1997)·2018·Department for Small Animals, United States·View original on PubMed →
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Original publication title: Serum α-proteinase inhibitor concentrations in dogs with exocrine pancreatic disease, chronic hepatitis or proteinuric chronic kidney disease.
- Species:
- dog
Plain-English summary
A group of dogs with chronic kidney disease (CKD) were found to have lower levels of a specific protein (alpha-proteinase inhibitor) in their blood compared to dogs with pancreatitis, exocrine pancreatic insufficiency, or chronic hepatitis. This suggests that the kidneys may be losing this protein, which could be contributing to the health issues seen in these dogs. In fact, 16% of the dogs with CKD had levels below what is considered normal. Understanding these protein levels could help veterinarians better manage kidney disease in dogs.
People also search for: dog kidney disease symptoms · low protein levels in dogs · treatment for chronic kidney disease in dogs
Abstract
Serum canine α-proteinase inhibitor (cα-PI) concentrations were evaluated in dogs with pancreatitis (n=24), exocrine pancreatic insufficiency (EPI; n=29), chronic hepatitis (CH; n=11) or proteinuric chronic kidney disease (CKD-P; n=61) to determine whether systemic proteinase/proteinase-inhibitor balance is altered in these conditions. Dogs with CKD-P had significantly lower cα-PI concentrations than dogs with pancreatitis, EPI or CH; 16% of dogs with CKD-P had serum cα-PI concentrations below the reference interval. Serum and urine cα-PI concentrations were inversely correlated in dogs with CKD-P, but not in dogs with CH. This suggests that renal loss of cα-PI contributes to decreased serum concentrations in dogs with CKD-P, while hepatic cα-PI synthesis with CH either is not compromised or is counterbalanced by extrahepatic production.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29871753/