Peer-reviewed veterinary case report
Poor prognosis in Shiba dogs with chronic enteropathy and clonal
By Ohmi, Aki et al.·Published in The Journal of veterinary medical science·2017·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Significance of clonal rearrangements of lymphocyte antigen receptor genes on the prognosis of chronic enteropathy in 22 Shiba dogs.
- Species:
- dog
Plain-English summary
A group of 22 Shiba dogs diagnosed with chronic enteropathy (CE) showed that those with certain genetic changes had a much shorter survival time. Specifically, 59% of these dogs tested positive for clonal rearrangement of their lymphocyte antigen receptor genes, which was linked to a median survival of just 48 days. In contrast, dogs without this genetic change lived significantly longer, with a median survival of 271 days. This suggests that the presence of these genetic changes may indicate a more severe form of the disease, similar to a type of lymphoma seen in humans.
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Abstract
Shiba dogs are predisposed to chronic enteropathy (CE) and have poorer prognosis than other dog breeds. The objective of this study was to investigate the significance of polymerase chain reaction for antigen receptor rearrangement (PARR) results on clinical findings and prognosis of Shiba dogs with CE. We retrospectively collected data on 22 Shiba dogs diagnosed as having CE. Fifty-nine percent of the dogs had clonality-positive results on PARR analysis. Furthermore, on histopathology, epitheliotropic behavior of small lymphocytes of the intestinal mucosa was observed significantly more frequently in dogs with clonal rearrangement of antigen receptor genes (P=0.027). The median overall survival time of clonality-positive dogs was 48 days (range, 4-239 days), compared to 271 days (range, 45-1,316+ days) in clonality-negative dogs. The median overall survival time of epitheliotropism-positive dogs was 76 days (range, 30-349 days) compared to 239 days (range, 4-1,316+ days) for epitheliotropism-negative dogs. Statistical analysis revealed that the clonality-positive result was associated with significantly shorter survival time (P=0.036). In contrast, presence or absence of epitheliotropism had no statistically significant effect on survival time (P=0.223). These cases might appropriately be diagnosed as small T-cell intestinal lymphoma; there are some common clinical and pathogenic features with human enteropathy-associated T-cell lymphoma type 2. The pathogenesis and poor prognosis for Shiba dogs with CE seem to be associated with this type of lymphoma, although further investigation is warranted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28781326/