Peer-reviewed veterinary case report
New combined PET and MRI scans to study cancer in 10 dogs
By Gutte, Henrik et al.·Published in Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2015·Department of Clinical Physiology·View original on PubMed →
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Original publication title: Simultaneous Hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 Dogs with Cancer.
- Species:
- dog
Plain-English summary
Ten dogs with cancer underwent a new imaging technique called hyperPET, which combines two types of scans to better understand their tumors. This method allowed veterinarians to see how the tumors were using energy and producing certain substances in real-time. The scans were completed in about two hours, and in nine of the dogs, they detected increased levels of a substance called lactate, which is often associated with tumor activity. The results suggest that this combined imaging approach could provide valuable information to help monitor treatment responses and improve outcomes for dogs with cancer.
People also search for: dog cancer treatment imaging · hyperPET for dogs · tumor lactate production in dogs · cancer diagnosis in dogs
Abstract
UNLABELLED: With the introduction of combined PET/MR spectroscopic (MRS) imaging, it is now possible to directly and indirectly image the Warburg effect with hyperpolarized (13)C-pyruvate and (18)F-FDG PET imaging, respectively, via a technique we have named hyperPET. The main purpose of this present study was to establish a practical workflow for performing (18)F-FDG PET and hyperpolarized (13)C-pyruvate MRS imaging simultaneously for tumor tissue characterization and on a larger scale test its feasibility. In addition, we evaluated the correlation between (18)F-FDG uptake and (13)C-lactate production. METHODS: Ten dogs with biopsy-verified spontaneous malignant tumors were included for imaging. All dogs underwent a protocol of simultaneous (18)F-FDG PET, anatomic MR, and hyperpolarized dynamic nuclear polarization with (13)C-pyruvate imaging. The data were acquired using a combined clinical PET/MR imaging scanner. RESULTS: We found that combined (18)F-FDG PET and (13)C-pyruvate MRS imaging was possible in a single session of approximately 2 h. A continuous workflow was obtained with the injection of (18)F-FDG when the dogs was placed in the PET/MR scanner. (13)C-MRS dynamic acquisition demonstrated in an axial slab increased (13)C-lactate production in 9 of 10 dogs. For the 9 dogs, the (13)C-lactate was detected after a mean of 25 s (range, 17-33 s), with a mean to peak of (13)C-lactate at 49 s (range, 40-62 s). (13)C-pyruvate could be detected on average after 13 s (range, 5-26 s) and peaked on average after 25 s (range, 13-42 s). We noticed concordance of (18)F-FDG uptake and production of (13)C-lactate in most, but not all, axial slices. CONCLUSION: In this study, we have shown in a series of dogs with cancer that hyperPET can easily be performed within 2 h. We showed mostly correspondence between (13)C-lactate production and (18)F-FDG uptake and expect the combined modalities to reveal additional metabolic information to improve prognostic value and improve response monitoring.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26338899/