Peer-reviewed veterinary case report
Dog has allergic reactions to two antibiotics at once
By Jeong, Yunho et al.·Published in Journal of veterinary science·2023·Department of Veterinary Internal Medicine and Institute of Veterinary Science, South Korea·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Simultaneous hypersensitivity reactions to trimethoprim-sulfamethoxazole and amoxicillin-clavulanate in a dog.
- Species:
- dog
Plain-English summary
A 5-year-old mixed-breed dog experienced severe allergic reactions after being given two different antibiotics, trimethoprim-sulfamethoxazole and amoxicillin-clavulanate. The dog developed a serious condition called drug-induced immune thrombocytopenia (DITP), which affects blood platelets, and also went into anaphylactic shock, a life-threatening reaction. After stopping the first antibiotic, the dog's platelet levels returned to normal, and the anaphylactic shock was treated with intensive care. Thankfully, the dog made a full recovery.
People also search for: dog allergic reaction to antibiotics · dog anaphylactic shock treatment · drug-induced immune thrombocytopenia in dogs
Abstract
Antibiotics are known to be able to cause hypersensitivity reactions through various mechanisms. We present a case of drug-induced immune thrombocytopenia (DITP) and anaphylactic shock occurring simultaneously in a dog after the administration of two classes of antibiotics, namely trimethoprim-sulfamethoxazole (TMP-SMX) and amoxicillin-clavulanate (AMC). The patient recovered completely from DITP on discontinuation of TMP-SMX and the anaphylactic shock caused by AMC was treated with intensive care. DITP is a rare adverse drug reaction (ADR), and anaphylactic shock is a life-threatening ADR. This is the first case report of a dog manifesting two types of hypersensitivity reactions caused by two antibiotics.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37904639/