Peer-reviewed veterinary case report
Simultaneous hypersensitivity reactions to trimethoprim-sulfamethoxazole and amoxicillin-clavulanate in a dog.
- Journal:
- Journal of veterinary science
- Year:
- 2023
- Authors:
- Jeong, Yunho et al.
- Affiliation:
- Department of Veterinary Internal Medicine and Institute of Veterinary Science · South Korea
- Species:
- dog
Abstract
Antibiotics are known to be able to cause hypersensitivity reactions through various mechanisms. We present a case of drug-induced immune thrombocytopenia (DITP) and anaphylactic shock occurring simultaneously in a dog after the administration of two classes of antibiotics, namely trimethoprim-sulfamethoxazole (TMP-SMX) and amoxicillin-clavulanate (AMC). The patient recovered completely from DITP on discontinuation of TMP-SMX and the anaphylactic shock caused by AMC was treated with intensive care. DITP is a rare adverse drug reaction (ADR), and anaphylactic shock is a life-threatening ADR. This is the first case report of a dog manifesting two types of hypersensitivity reactions caused by two antibiotics.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37904639/