Peer-reviewed veterinary case report
Single-session radiation treats brain tumors in dogs
By Kelsey, Krista L et al.·Published in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·2018·Department of Clinical Sciences·View original on PubMed →
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Original publication title: Single fraction stereotactic radiation therapy (stereotactic radiosurgery) is a feasible method for treating intracranial meningiomas in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with brain tumors called meningiomas underwent a special type of radiation therapy known as stereotactic radiosurgery. This treatment involved delivering a high dose of radiation directly to the tumor in a single session. While some dogs experienced side effects, including a decline in their neurological function, over half of the dogs showed improvement in their condition after treatment. On average, the dogs lived for about 519 days after the procedure, with many surviving for over a year. This method appears to be a promising option for treating dogs with these types of tumors.
People also search for: dog brain tumor treatment · stereotactic radiosurgery for dogs · meningioma in dogs survival rate
Abstract
The aim of this retrospective, pilot study was to evaluate stereotactic radiosurgery as a method for treating intracranial meningiomas in dogs. Included dogs had an imaging diagnosis of presumed intracranial meningioma, were treated using a standardized stereotactic radiosurgery protocol, and had a follow-up time of >6 months after stereotactic radiosurgery. A single fraction of 16 Gy stereotactic radiosurgery was delivered to the tumor, with an internal simultaneously integrated boost to a total dose of 20-24 Gy to the central portion of the tumor. Thirty-two dogs were sampled. One dog was euthanized in the periprocedural period, and 10 of the remaining 31 dogs (31%) experienced an acute adverse event (defined as declining neurologic function due to tumor progression or treatment-associated complication within the first 6 months after stereotactic radiosurgery), three of which were fatal. Too few subjects (n = 6) had cross-sectional imaging after stereotactic radiosurgery to determine an objective response rate; however, 17/30 (57%) dogs assessed for response had a perceived clinical benefit from treatment. The overall median survival time was 519 days (95% confidence interval: 330-708 days); 64% and 24% of dogs were alive at 1 and 2 years after stereotactic radiosurgery, respectively. Dogs with infratentorial tumor location and high gradient indices had shorter survival. There were no factors identified which were predictive of acute adverse event. Survival times reported herein are similar to what has previously been reported for other stereotactic and traditional fractionated radiotherapy protocols. Findings therefore supported the use of stereotactic radiosurgery as an alternative method for treating dogs with presumed intracranial meningiomas.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29873144/