Peer-reviewed veterinary case report
Horse with chronic diarrhea and weight loss - what could it be?
By Herraez, P et al.·Published in Veterinary pathology·2001·Department of Pathobiology, United States·View original on PubMed →
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Original publication title: Small intestine large granular lymphoma in a horse.
- Species:
- horse
Plain-English summary
A 12-year-old Appaloosa gelding was taken to the Texas Veterinary Medical Center because he had been experiencing ongoing diarrhea and losing weight. After he passed away, a thorough examination revealed many oval, crater-like sores in his small intestine. The cells from these sores were found to be cancerous, specifically a type called large granular lymphoma, which is a cancer of certain immune cells. This particular case was unusual because the cancer was only found in the small intestine and did not spread to nearby lymph nodes. Unfortunately, the treatment options were not applicable since the horse had already died, and the findings confirmed a serious condition.
Abstract
A 12-year-old Appaloosa gelding was referred to the Texas Veterinary Medical Center with a history of chronic diarrhea and weight loss. At necropsy, numerous oval, craterlike ulcers were observed throughout the small intestine. Histologically, these lesions were composed of a neoplastic proliferation of round cells with intracytoplasmic phosphotungstic acid-hematoxylin-positive granules. The tumor cells stained positively for the CD3 antigen and negatively for a B-cell marker. A diagnosis of large granular lymphoma was based on the morphologic and immunohistochemical characteristics of the neoplasm. The postmortem presentation of this case depicted unusual multifocal, ulcerative lymphomatous lesions throughout the small intestine without involvement of the regional lymph nodes. The histologic and ultrastructural morphology of the neoplastic lymphocytes was similar to that in previously reported cases of abdominal equine large granular lymphomas, but in this case the neoplasm was restricted to the small intestine.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11280380/