Peer-reviewed veterinary case report
Different types of canine T cell lymphoma affect survival times
By Deravi, Nariman et al.·Published in Veterinary immunology and immunopathology·2017·Department of Pathobiology, Canada·View original on PubMed →
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Original publication title: Specific immunotypes of canine T cell lymphoma are associated with different outcomes.
- Species:
- dog
Plain-English summary
A study looked at different types of T cell lymphoma in dogs to see how they affect survival and disease progression. They found that dogs with gastrointestinal T cell lymphoma had shorter survival times compared to those with multicentric T cell lymphoma. Among dogs with multicentric T cell lymphoma, certain immunotypes were linked to longer survival and better progression-free intervals. Unfortunately, dogs with multicentric T cell lymphoma and leukemia had shorter survival times. Treatment options included chemotherapy, but factors like body weight and sex did not significantly change the outcomes.
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Abstract
Canine lymphoma is a heterogeneous disease with many different subtypes. Lymphoma of T cell type in particular is variable in outcome, and includes subtypes with non-progressive, slowly- and rapidly-progressive disease course. Association of immunotype with disease course is incompletely defined. Here, results of flow cytometric immunotyping of 127 canine T cell lymphomas were analyzed in relation to survival and progression free interval. Samples originated from 101 multicentric, 8 mediastinal, 6 cutaneous, 5 hepatosplenic, 5 gastrointestinal and 2 other anatomic subtypes of T cell lymphoma. Compared to multicentric T cell lymphoma, gastrointestinal lymphoma had shorter survival and progression free interval, and hepatosplenic lymphoma had shorter survival. Among dogs with multicentric T cell lymphoma, immunotypes of CD4/CD8/MHCII, CD4/CD8/MHCIIand CD4/CD8/MHCIIwere associated with longer survival times than the immunotype of CD4/CD8/MHCII, and immunotypes of CD4/CD8/MHCII, CD4/CD8/MHCII, and CD4/CD8/MHCIIwere associated with longer progression free intervals. Dogs with multicentric T cell lymphoma and concurrent leukemia had shorter survival but similar progression free interval compared to those without leukemia. Body weight, sex, hypercalcemia, cell size, expression of CD3 and use of combination or single agent chemotherapy did not significantly affect outcome of multicentric TCL.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28895866/