Peer-reviewed veterinary case report
Dog with anemia and low platelets helped by stem cell therapy
By L.G. Santos et al.·Published in Arquivo Brasileiro de Medicina Veterinária e Zootecnia·2024·View original on DOAJ →
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Original publication title: Stem cell therapy as adjunctive in the management of anemia and thrombocytopenia partially responsive to corticosteroid in a dog treated with Phenobarbital - case report
- Species:
- dog
Plain-English summary
A dog with anemia and low platelet counts (thrombocytopenia) related to phenobarbital treatment was given a combination of corticosteroids and stem cell therapy. After the first stem cell treatment, the dog's platelet count improved but started to drop again after three weeks. However, the vet was able to reduce the corticosteroid dosage, and subsequent stem cell treatments led to further increases in platelet counts, which remained stable without needing to raise the steroid dose. Overall, the stem cell therapy was safe and helped manage the dog's condition, although more treatments might be needed to keep platelet levels up long-term.
People also search for: dog anemia treatment · dog low platelet count stem cell therapy · phenobarbital side effects in dogs
Abstract
ABSTRACT This report describes a dog with anemia and ITP, associated with phenobarbital, treated with prednisolone with a good response after association with three intravenous transplantations of 2.5x106 allogenic Mesenchymal Stem-Cells. After the first transplantation, the number of platelets had an improvement, but started to decrease after three weeks. However, the dose of corticosteroid could be reduced. After the second and third administrations, new increases were observed. The platelet count varied from 102,000 to 365,000 until the end of follow-up and without increase of prednisolone doses. Although phenobarbital therapy has been associated with thrombocytopenia, it was not possible to change the anti-convulsant therapy. The response to corticosteroid-based therapy was partial. Cell therapy was followed by an improvement in platelet count with no observed side effects and therefore could be considered safe. Effects on platelet count were transitory, but until the end of follow-up, no severe thrombocytopenia was observed. Based on the observation that platelet numbers dropped a few weeks after cell therapy, more applications would be beneficial in order to maintain higher platelet counts.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1590/1678-4162-13136