Peer-reviewed veterinary case report
Striatal but not frontal cortical up-regulation of the epidermal growth factor receptor in rats exposed to immune activation in utero and cannabinoid treatment in adolescence.
- Journal:
- Psychiatry research
- Year:
- 2016
- Authors:
- Idrizi, Rejhan et al.
- Affiliation:
- The Florey Institute of Neuroscience and Mental Health · Australia
- Species:
- rodent
Abstract
In utero maternal immune activation (MIA) and cannabinoid exposure during adolescence constitute environmental risk factors for schizophrenia. We investigated these risk factors alone and in combination ("two-hit") on epidermal growth factor receptor (EGFR) and neuregulin-1 receptor (ErbB4) levels in the rat brain. EGFR but not ErbB4 receptor protein levels were significantly increased in the nucleus accumbens and striatum of "two-hit" rats only, with no changes seen at the mRNA level. These findings support region specific EGF-system dysregulation as a plausible mechanism in this animal model of schizophrenia pathogenesis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27138815/