Peer-reviewed veterinary case report
Stromal cell therapy for chronic mouth inflammation in cats
By Rivas, Iris L et al.·Published in Journal of feline medicine and surgery·2023·Department of Pathology, United States·View original on PubMed →
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Original publication title: Stromal cell therapy in cats with feline chronic gingivostomatitis: current perspectives and future direction.
- Species:
- cat
Plain-English summary
A cat with chronic mouth pain due to a condition called feline chronic gingivostomatitis (FCGS) may struggle with eating and show signs of discomfort. The usual treatment involves removing all of the cat's teeth, but some cats still suffer and require ongoing medication or even euthanasia. Recent research suggests that using special cells from fat (adipose-derived mesenchymal stromal cells) after tooth extraction could improve treatment outcomes for these cats. This new approach is being studied to see if it can help more cats recover from this painful condition.
People also search for: cat mouth pain treatment · feline chronic gingivostomatitis management · cat tooth extraction recovery
Abstract
Feline chronic gingivostomatitis (FCGS) is a painful, immune-mediated, oral mucosal inflammatory disease in cats. The etiology of FCGS remains unclear, with evidence pointing potentially toward a viral cause. Full-mouth tooth extraction is the current standard of care, and cats that are non-responsive to extraction therapy may need lifelong medical management and, in some cases, euthanasia. Adipose-derived mesenchymal stromal cells (adMSCs) have been demonstrated to have advantages in the treatment and potentially the cure of non-responsive FCGS in cats. Therefore, adMSCs have attracted a series of ongoing clinical trials in the past decade. AdMSC therapy immediately after full-mouth tooth extraction was not explored, and we postulate that it may benefit the overall success rate of FCGS therapy. Here, we aim to summarize the current knowledge and impact of adMSCs for the therapeutic management of FCGS and to suggest a novel modified approach to further increase the efficacy of FCGS treatment in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37548494/