Peer-reviewed veterinary case report
Parotid gland changes in dogs with natural Leishmania infantum
By Fonseca, Clarisse Maria Barbosa et al.·Published in Archives of oral biology·2021·Master Program in Science and Health, Brazil·View original on PubMed →
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Original publication title: Structure of the parotid gland in natural infection by Leishmania infantum in Canis familiaris.
- Species:
- dog
Plain-English summary
A group of dogs infected with Leishmania infantum, a parasite that can cause serious health issues, had their parotid glands examined to see how the infection and treatment with Allopurinol affected them. The study looked at 14 dogs, some of which were treated with Allopurinol for 90 days. Results showed that both treated and untreated dogs had changes in the structure of their parotid glands, including enlarged gland areas and altered cell structures. These findings indicate that the infection and treatment can significantly impact the health of the parotid gland in dogs.
People also search for: dog Leishmania infection treatment · Allopurinol for dogs · dog parotid gland problems
Abstract
OBJECTIVE: The objective of this study was to perform a histopathological, morphometric and proteomic study of the parotid gland of dogs naturally infected with Leishmania infantum treated and not treated with Allopurinol. DESIGN: Parotid glands from 14 dogs were used, divided into two groups: untreated and treated with oral allopurinol (20 mg / kg, once daily for 90 days). After adequate dissection, the organs were submitted to histopathological, histomorphometric and immunohistochemical techniques, using the monoclonal anti-β-catenin antibody. RESULTS: Histopathological evaluation of treated and untreated groups showed acinar hypertrophy, structural disorganization of the nucleus and cytoplasm. There was an increase in the area and perimeter of the parotid acini in the experimental groups. The immunostaining of the β-catenin protein in the membrane was severely reduced in the treated and untreated groups. CONCLUSIONS: These findings suggest that Leishmania infantum infection and treatment with Allopurinol alter the tissue structure of the parotid gland in dogs, promoting an increase in the acinar volume and a decrease in the expression of β-catenin in cell membranes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33601301/