Peer-reviewed veterinary case report
Cat with skin nodules caused by rare Flavodon flavus fungus
By Grandinetti, J A B et al.·Published in Research in veterinary science·2025·Grupo Argentino de Dermatologí·View original on PubMed →
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Original publication title: Subcutaneous hyalohyphomycosis in a domestic cat caused by Flavodon flavus, an under-recognized fungal pathogen.
- Species:
- cat
Plain-English summary
A 3-year-old indoor cat developed nodules on all four legs that continued to grow over time. After tests showed a fungal infection caused by Flavodon flavus, the vet started treatment with an antifungal medication called itraconazole, which only helped a little at first. When the cat's condition didn't improve after 90 days, the vet added another medication, potassium iodide, to the treatment plan. This combination worked well, and the cat's skin lesions completely cleared up after about 135 days, with no signs of them coming back since then.
People also search for: cat skin nodules treatment · Flavodon flavus cat infection · antifungal medication for cats
Abstract
This report describes the first documented case of subcutaneous hyalohyphomycosis caused by Flavodon flavus in a domestic cat. A 3-year-old spayed indoor cat presented with progressive cutaneous nodules on all four limbs. Histopathology revealed a pyogranulomatous inflammatory response with fungal elements, and fungal culture followed by molecular identification confirmed F. flavus as the etiologic agent. The cat tested negative for FIV and FeLV. Initial treatment with oral itraconazole (5 mg/kg/day) resulted in partial improvement. Due to stagnation in clinical response by day 90, oral potassium iodide (5 mg/kg/day) was added. Combined therapy led to complete resolution of lesions by day 135, and treatment was extended for an additional 60 days. No recurrence has been observed to date. This case highlights the emerging role of F. flavus-an environmental basidiomycete previously unrecognized as a feline pathogen-as a potential cause of subcutaneous mycoses in cats. Long-term antifungal treatment and close monitoring are recommended due to the risk of relapse.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40819490/