Peer-reviewed veterinary case report
Dog with unusual sublingual reactive histiocytosis explained
By Cornegliani, Luisa et al.·Published in Journal of veterinary dentistry·2011·Clinica Veterinaria San Siro, Italy·View original on PubMed →
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Original publication title: Sublingual reactive histiocytosis in a dog.
- Species:
- dog
Plain-English summary
A Miniature Pinscher was brought in with unusual growths under its tongue that were causing concern. After thorough testing, the vet diagnosed the dog with a rare condition called reactive histiocytosis, which involves an abnormal increase of certain immune cells. The dog was treated with a combination of tetracycline and niacinamide for eight months. Two years later, there were no signs of the growth returning, and the dog was doing well.
People also search for: dog tongue growth · Miniature Pinscher histiocytosis treatment · oral lesions in dogs · dog immune system disorders
Abstract
Lingual lesions are relatively uncommon in dogs and are mostly represented by neoplasms and glossitis secondary to trauma or infections. Reactive histiocytosis is an uncommon, poorly understood, reactive disorder characterized by proliferation of activated, interstitial, dendritic, antigen-presenting cells associated with lymphocytes and neutrophils with a specific angiocentric orientation and occasional angioinvasion and angiodestruction. Clinically, the disease has a waxing and waning behavior with possible response to treatment and regression, or progression to multiple lesions and internal organ involvement. This case report describes an unusual sublingual presentation of reactive histiocytosis in a Miniature Pinscher dog. The diagnosis was obtained by clinical and histopathological exclusion of other causes, detection of the characteristic microscopic growth pattern, and by immunocytochemistry. Histiocytic cells were vimentin, CD18, CD11c, and CD1c positive consistent with a dendritic cell origin. Anti-BCG stain (Bacillus Calmette and Guerin) was negative for etiological agents. The dog was treated with oral administration of tetracycline and niacinamide during an 8-month period. There was no indication of recurrence of the sublingual mass 2-years following treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22206142/