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Peer-reviewed veterinary case report

Successful clinical remission of feline squamous cell carcinoma after electrochemotherapy as the sole therapeutic approach - a quadruple case report

Journal:
Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Year:
2025
Authors:
L.T. Machado et al.
Species:
cat

Plain-English summary

This study looked at four cats with squamous cell carcinoma, a type of skin cancer that often appears on the face and can be hard to treat. The cats were treated with electrochemotherapy, which involves using electricity to help a chemotherapy drug work better. All four cats had facial lesions but did not have any spread of the cancer to their bones or other parts of the body. After treatment, the lesions completely went away, and the cats maintained a good quality of life with minimal impact on their appearance. Overall, the treatment was successful in achieving complete remission of the cancer.

Abstract

ABSTRACT Squamous cell carcinoma is a common neoplasm in felines that mainly affects the face, an area that is difficult to treat. Due to its high frequency, it is a challenge in the Oncology Clinic. The aim of this study is to report the total remission of lesions caused by SCC in four felines after electrochemotherapy treatment as a single therapy. The cats did not have bone lysis or lymphatic or distant metastases. Bleomycin, 15 U/m2, was administered in all patients intravenously as a bolus, five minutes before the start of electroporations. All patients had facial lesions and achieved good local control, with little interference in quality of life and the anatomy of the affected site.

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Original publication: https://doi.org/10.1590/1678-4162-13493