Peer-reviewed veterinary case report
Dog recovers after vincristine overdose for low platelets
By Poirier, Maude et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2022·Department of Small Animal Emergency and Critical Care, United States·View original on PubMed →
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Original publication title: Successful management and recovery of a dog with immune-mediated thrombocytopenia following vincristine overdose.
- Species:
- dog
Plain-English summary
A 2-year-old female Toy Fox Terrier was brought to the vet after accidentally receiving a tenfold overdose of vincristine, a medication that can affect blood platelets. The dog showed serious symptoms, including severe gastrointestinal issues, muscle tremors, and weakness. The veterinary team provided intensive supportive care and used new treatments like folinic acid, glutamic acid, and Tbo-filgrastim to help her recover. After 12 days in the hospital, she was sent home and fully recovered within a month, with no lasting effects from the overdose.
People also search for: dog vincristine overdose treatment · Toy Fox Terrier muscle tremors · dog gastrointestinal issues after medication
Abstract
OBJECTIVE: To describe the management and outcome of a dog following a 10-fold dosing error of vincristine. CASE SUMMARY: A 2-year-old neutered female Toy Fox Terrier presenting for immune-mediated thrombocytopenia was administered an accidental overdose of vincristine (0.2 mg/kg [2.71 mg/m]). The dog was managed for severe gastrointestinal signs, neutropenia, and neurological consequences secondary to the overdose. Neurological signs included diffuse muscle tremors, limb hyperextension, and myalgia during the dog's hospitalization. Medical management consisted of aggressive supportive care in addition to novel strategies, including folinic acid, glutamic acid, and Tbo-filgrastim. The dog was discharged from the hospital after 12 days of hospitalization and recovered completely within a month of the overdose with no lasting consequences. NEW OR UNIQUE INFORMATION PROVIDED: This is the first report of the successful management of severe vincristine overdose in a dog. Therapy included the use of Tbo-filgrastim, folinic acid, and glutamic acid along with aggressive supportive care.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35129277/