Peer-reviewed veterinary case report
Dog with lung lymphomatoid granulomatosis treated successfully
By Hatoya, Singo et al.·Published in The Journal of veterinary medical science·2011·Department of Advanced Pathobiology, Japan·View original on PubMed →
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Original publication title: Successful management with CHOP for pulmonary lymphomatoid granulomatosis in a dog.
- Species:
- dog
Plain-English summary
A 3-year-old spayed female miniature dachshund was brought to the vet because she was vomiting and not eating. Tests, including X-rays and a CT scan, showed unusual spots in her lungs, and a biopsy confirmed she had pulmonary lymphomatoid granulomatosis, a type of cancer affecting the lungs. The dog was treated with a chemotherapy regimen called CHOP and remarkably survived for over 1,000 days after starting treatment. This case highlights a successful approach to managing this rare lung condition in dogs.
People also search for: dog vomiting and not eating · miniature dachshund lung cancer treatment · pulmonary lymphomatoid granulomatosis in dogs
Abstract
A 3-year-old, spayed female miniature dachshund was presented for vomiting and anorexia. Thoracic radiographs and CT scan revealed abnormal pulmonary opacities at bilateral caudal lobe. Cytological analysis of the pulmonary mass revealed the presence of large lymphohistiocytic cells and small lymphocytes with occasional neutrophils and plasma cells. An open lung biopsy was performed and a diagnosis of pulmonary lymphomatoid granulomatosis (LYG) was made. The dog was administered CHOP based therapy (modified UW-25), and it survived for 1,022 days after admission. Immunohistochemistry revealed pulmonary lesions consisted of many CD79a positive B cells aggregation and proliferation with prominent angiocentric pattern. This was the first case of canine pulmonary LYG managed by CHOP chemotherapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21139353/