Successful therapy of a dog with trapped neutrophil syndrome using a combination of cyclosporine and prednisolone: a case report.

Abstract

Trapped Neutrophil Syndrome (TNS) is a rare, fatal, autosomal recessive disease in Border Collies. A 7-month-old female Border Collie with TNS presented with fever, diarrhea, occasional vomiting, lameness, and severe neutropenia. The diagnosis was confirmed by bone marrow examination and vacuolar protein sorting-associated protein 13B (VPS13B) gene mutation analysis. Initial treatment with prednisolone improved symptoms; however, relapse occurred during tapering, and the addition of cyclosporine resolved the symptoms, allowing successful tapering of prednisolone. The dog remained symptom-free for 7.4 months and survived for 33 months. Cyclosporine may be associated with increased C-X-C chemokine receptor type 4 mRNA expression, possibly reducing the risk of infection and fever. Based on these findings, a combination of cyclosporine and prednisolone may represent a potential treatment option for TNS.