Peer-reviewed veterinary case report
Dog with trapped neutrophil syndrome treated successfully
By Miyamoto, Ryo et al.·Published in The Journal of veterinary medical science·2026·Iwate University, Japan·View original on PubMed →
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Original publication title: Successful therapy of a dog with trapped neutrophil syndrome using a combination of cyclosporine and prednisolone: a case report.
- Species:
- dog
Plain-English summary
A 7-month-old female Border Collie was brought in with fever, diarrhea, occasional vomiting, and lameness due to a rare condition called Trapped Neutrophil Syndrome (TNS). After confirming the diagnosis through tests, the vet started her on prednisolone, which helped at first but led to a relapse when the dose was reduced. Adding cyclosporine to her treatment plan resolved her symptoms, allowing the vet to safely taper off the prednisolone. The dog remained symptom-free for over seven months and lived for 33 months after starting treatment.
People also search for: Border Collie trapped neutrophil syndrome treatment · dog fever and diarrhea · cyclosporine for dogs
Abstract
Trapped Neutrophil Syndrome (TNS) is a rare, fatal, autosomal recessive disease in Border Collies. A 7-month-old female Border Collie with TNS presented with fever, diarrhea, occasional vomiting, lameness, and severe neutropenia. The diagnosis was confirmed by bone marrow examination and vacuolar protein sorting-associated protein 13B (VPS13B) gene mutation analysis. Initial treatment with prednisolone improved symptoms; however, relapse occurred during tapering, and the addition of cyclosporine resolved the symptoms, allowing successful tapering of prednisolone. The dog remained symptom-free for 7.4 months and survived for 33 months. Cyclosporine may be associated with increased C-X-C chemokine receptor type 4 mRNA expression, possibly reducing the risk of infection and fever. Based on these findings, a combination of cyclosporine and prednisolone may represent a potential treatment option for TNS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41485978/