Peer-reviewed veterinary case report
Puppy with 5-fluorouracil poisoning saved by hemodialysis
By Henry, Jessica S et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2023·Veterinary Specialty Hospital of San Diego, United States·View original on PubMed →
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Original publication title: Successful treatment of 5-fluorouracil toxicosis with hemodialysis.
- Species:
- dog
Plain-English summary
A 4-month-old female Golden Retriever was rushed to the emergency room after eating a large amount of a cream containing 5-fluorouracil (5-FU), which caused her to have severe seizures and fall into a coma. To help her recover, the veterinarians used hemodialysis, a treatment that helps remove toxins from the blood. After this treatment, the puppy showed significant improvement and was able to go home three days later. Although she experienced some temporary blood cell issues, these were treated successfully, and she is now completely healthy with no lasting effects a year later.
People also search for: puppy seizures treatment · 5-fluorouracil poisoning in dogs · hemodialysis for dogs
Abstract
OBJECTIVE: To describe the successful treatment of lethal dose 5-fluorouracil (5-FU) toxicosis using hemodialysis. CASE SUMMARY: A 4-month-old intact female Golden Retriever was presented to the emergency department after ingesting 20 g of 5% 5-FU cream. The puppy developed refractory seizures and became comatose with uncontrolled tonic-clonic convulsions. Because of the low molecular weight and minimal protein binding of 5-FU, a single hemodialysis treatment was employed for detoxification. The puppy improved clinically posttreatment and was successfully discharged 3 days after admission. Postingestion leukopenia and neutropenia occurred but were responsive to treatment with filgrastim. The puppy is neurologically normal and has no lasting effects 1 year postingestion. NEW OR UNIQUE INFORMATION PROVIDED: To the authors' knowledge, this is the first reported case in veterinary medicine of a potentially fatal 5-FU ingestion that has been treated with intermittent hemodialysis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36883466/