Peer-reviewed veterinary case report
Dog with acute kidney injury after human serum albumin
By Almeida, Mariana et al.·Published in Journal of the American Animal Hospital Association·2023·From Lumbry Park Veterinary Specialists, United Kingdom·View original on PubMed →
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Original publication title: Successful Use of Mycophenolate Mofetil as Adjunct to Prednisolone for Treatment of Acute Kidney Injury Secondary to Human Serum Albumin Administration in a Dog.
- Species:
- dog
Plain-English summary
A 4.8-year-old male Labrador Retriever developed serious kidney problems after receiving a human protein treatment called human serum albumin (HSA) following surgery for a severe infection. Nineteen days later, he showed signs of acute kidney injury, including high levels of protein in his urine. The veterinarian quickly started treatment with a combination of prednisolone (a steroid) and mycophenolate mofetil (an immunosuppressant), which successfully resolved his kidney issues and returned his protein levels to normal. This case highlights the potential effectiveness of mycophenolate mofetil in treating kidney injury caused by HSA.
People also search for: dog kidney problems after treatment · Labrador Retriever kidney injury treatment · mycophenolate mofetil for dogs
Abstract
The use of human serum albumin (HSA) is described in dogs receiving critical care. However, despite the high degree of homology, anaphylactic and delayed hypersensitivity reactions are reported. Delayed type III hypersensitivity reactions can lead to glomerulonephritis and acute kidney injury (AKI). Undiluted 20% HSA was administered to a 4.8 yr old intact male Labrador Retriever with severe hypoalbuminemia, following surgical management of septic peritonitis of gastrointestinal origin. Nineteen days after HSA administration, the dog developed peracute high magnitude renal proteinuria and AKI. Rapid immunosuppression, using a combination of prednisolone and mycophenolate mofetil, resulted in full resolution of AKI, hypoalbuminemia, and proteinuria. Addition of mycophenolate mofetil may have resulted in the first documented case of full renal recovery from hypersensitivity-induced AKI caused by HSA administration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36584313/