Peer-reviewed veterinary case report
Dog with brain tumor treated successfully with prednisolone
By Takahashi, Tomoko et al.·Published in The Journal of veterinary medical science·2021·Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Successful use of prednisolone and radiation therapy in a dog with intracranial histiocytic sarcoma.
- Species:
- dog
Plain-English summary
A 9-year-old spayed female Pembroke Welsh Corgi was brought in for seizures, and an MRI showed a mass in her brain. The vet treated her with prednisolone, which helped shrink the tumor, and then she received radiation therapy, leading to the complete disappearance of the mass. Unfortunately, her neurological symptoms worsened later, and she was euthanized after 164 days. Despite the sad outcome, the combination of prednisolone and radiation therapy showed promise in treating this type of brain tumor in dogs.
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Abstract
The ideal treatment for intracranial histiocytic sarcoma (HS) remains unclear. Herein, we report a case of intracranial HS that was successfully treated using prednisolone and radiation therapy. The patient was a 9-year-old spayed female Pembroke Welsh Corgi that presented with epileptic seizures. Magnetic resonance imaging revealed a contrast-enhancing mass adjacent to the right piriform lobe. Prednisolone administration (1 mg/kg/day) decreased the lesion size. Additional palliative radiation therapy (total dose, 37 Gy) resulted in complete disappearance of the lesion. However, on day 164, the dog's neurological signs deteriorated, and she was euthanized. Necropsy revealed an intracranial metastasis of HS via the cerebrospinal fluid without any extracranial metastasis. Nonetheless, combined prednisolone and radiation therapy might be effective in treating intracranial HS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34556593/