Peer-reviewed veterinary case report
Dog with crusting skin linked to glucagon-secreting tumor outside
By Mizuno, Takuya et al.·Published in Veterinary dermatology·2009·Yamaguci University, Japan·View original on PubMed →
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Original publication title: Superficial necrolytic dermatitis associated with extrapancreatic glucagonoma in a dog.
- Species:
- dog
Plain-English summary
An 11-year-old Shih Tzu was brought to the vet because of crusty, red skin mainly on its belly and tail. After tests and a thorough examination, the dog was diagnosed with superficial necrolytic dermatitis, which was linked to a glucagon-secreting tumor outside the pancreas. Unfortunately, the tumor had spread to several organs, including the spleen and liver. This serious condition requires specialized treatment, and the prognosis can be poor due to the tumor's aggressive nature.
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Abstract
An 11-year-old Shih Tzu presented with crusting and erythema, mainly on the abdomen and the root of the tail. Based on histopathological findings, blood examinations and necropsy findings, the condition was diagnosed as superficial necrolytic dermatitis associated with a glucagon-secreting extrapancreatic neuroendocrine tumour. Gross necropsy revealed tumour invasion into the spleen, liver, adrenal glands and mesenteric lymph nodes. Immunohistochemical analysis of the neoplastic cells revealed that the tumour was a glucagonoma, consistent with earlier findings of persistent glucagonaemia and hypoaminoacidaemia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19152590/