Peer-reviewed veterinary case report
Dog with skin sores and low blood sugar from pancreatic tumor
By Isidoro-Ayza, M et al.·Published in Veterinary pathology·2014·Veterinary School, Spain·View original on PubMed →
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Original publication title: Superficial necrolytic dermatitis in a dog with an insulin-producing pancreatic islet cell carcinoma.
- Species:
- dog
Plain-English summary
A 10-year-old dog was brought in for convulsions and skin problems, including thickened patches on the abdomen, eyelids, and paw pads. Tests showed low blood sugar and high insulin levels, leading to the discovery of a tumor in the pancreas. The tumor was surgically removed, but the dog did not improve and was eventually euthanized. The skin issues were linked to the cancer, a condition known as superficial necrolytic dermatitis, which can occur with certain tumors. Unfortunately, the cancer had spread to other organs by the time of the dog's passing.
People also search for: dog convulsions and skin problems · pancreatic cancer in dogs · superficial necrolytic dermatitis treatment
Abstract
A 10-year-old dog presented with convulsive crisis and symmetrical hyperkeratotic cutaneous lesions affecting the abdomen, inguinal area, eyelids, muzzles, both pinnae, and all the paw pads. Hypoglycemia and hyperinsulinemia were the main biochemical findings. A mass 2 cm in diameter was detected within the left pancreatic lobe by ultrasonography. It was surgically removed and histologically and immunohistochemically diagnosed as an insulin-producing pancreatic islet cell carcinoma. The animal was eventually euthanized due to lack of clinical improvement. At necropsy, metastatic nodules were observed in the pancreatic lymph nodes and liver. Histopathological findings of cutaneous lesions were highly suggestive of superficial necrolytic dermatitis and were interpreted as a paraneoplastic syndrome derived from the islet cell carcinoma. To the authors' knowledge, this is the first report of superficial necrolytic dermatitis associated with an insulin-producing pancreatic neuroendocrine carcinoma in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24021558/