Peer-reviewed veterinary case report
Probiotic SF68 effects on kidney health in dogs with chronic disease
By López, Ignacio et al.·Published in The veterinary quarterly·2026·Department Medicina y Cirugí, Spain·View original on PubMed →
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Original publication title: Supplementation with(SF68) and its association with biochemical parameters and inflammatory biomarkers related to renal impairment in dogs with chronic kidney disease.
- Species:
- dog
Plain-English summary
A group of dogs with chronic kidney disease (CKD) received a probiotic supplement called SF68 for 60 days to see if it would help their kidney function. The dogs that took the probiotic showed lower levels of certain harmful substances in their blood, which can indicate kidney problems, compared to those that received a placebo. Additionally, the probiotic group did not experience an increase in protein in their urine or high blood pressure, which were observed in the placebo group. Overall, the probiotic seemed to improve kidney health and reduce some symptoms associated with CKD.
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Abstract
To investigate the influence of probiotic supplementation on parameters of renal function, dogs with chronic kidney disease (CKD) received a commercial probiotic formulation containingSF68 ( = 8) or placebo ( = 8) for 60 days. Gut microbiome was investigated by comparing with healthy dogs ( = 10). Blood biochemistry, urinalysis, inflammatory and oxidative markers, uremic toxins and blood pressure were monitored. Higher presence offamily,bacterial species andgroup was observed in dogs with CKD when compared with healthy dogs. Adding the probiotic to the diet decreased the abundance ofProbiotic treatment resulted in a significant reduction in plasma concentrations of symmetric dimethylarginine (SDMA), from 1.50 ± 0.18 to 1.35 ± 0.16 µmol/l ( = 0.008), and indoxyl sulfate (IxS), from 19.1 ± 6.8 to 12.8 ± 4.8 µmol/l ( = 0.04). Cytokine inflammatory markers did not show significant changes. An increase in urine protein-to-creatine ratio, 1.5 ± 0.6 vs 1.2 ± 0.5, and in systolic blood pressure, 163 ± 11 vs 144 ± 6 mmHg ( = 0.033), was observed in the placebo group but not in dogs receiving probiotic. In conclusion, feedingSF68 to dogs with CKD results in changes in intestinal microbiota that are associated with a decrease in plasma concentrations of IxS and SDMA and a reduction in proteinuria and systolic blood pressure.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/42056070/