Peer-reviewed veterinary case report
Supportive care for dog with leishmaniosis and kidney disease
By Sänger, Florian et al.·Published in Pathogens (Basel, Switzerland)·2024·LMU Small Animal Clinic, Germany·View original on PubMed →
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Original publication title: Supportive Treatment of a Dog with Leishmaniosis and Severe Glomerulopathy with Immunoadsorption.
- Species:
- dog
Plain-English summary
A 3-year-old female mix-breed dog was brought in because she was vomiting and had diarrhea. She also had swollen lymph nodes and showed signs of kidney issues, with high levels of protein in her urine and elevated creatinine levels. After being diagnosed with leishmaniosis (a parasitic infection) and kidney disease, the vet started her on fluids, medications, and a special diet. When her condition didn’t improve, she received advanced treatments including hemodialysis and immunoadsorption to help remove harmful substances from her blood. Thankfully, her kidney function improved, and she was discharged after two and a half weeks. Two years later, she remains healthy with normal kidney levels.
People also search for: dog vomiting and diarrhea · leishmaniosis treatment in dogs · dog kidney disease recovery · immunoadsorption for dogs · dog swollen lymph nodes treatment
Abstract
A three-year-old, intact female mix-breed dog, weighing 30 kg, was presented due to vomitus and diarrhea. At presentation, the patient had a slightly reduced general condition and moderately enlarged mandibular and popliteal lymph nodes. The initial blood work showed severe azotemia and hypoalbuminemia. In the urinalysis, marked proteinuria with a urine protein/creatinine ratio (UPC) of 4.69 was found. Further workup showed a high leishmania antibody titer. The dog was diagnosed with leishmaniosis and glomerulonephritis. Initial treatment consisted of intravenous fluid therapy, allopurinol, miltefosine, amlodipine, clopidogrel, and a diet with a low purine content. Creatinine temporarily decreased but increased again after three days. For further supportive treatment, intermittent hemodialysis in combination with hemoperfusion with the cytosorbadsorber was performed. A total blood volume of 17.7 L was processed within three hours. Thereafter, immunoadsorption (IA) was performed with the COM.TECand ADAsorbplatforms and a LIGASORBadsorber to eliminate circulating immunocomplexes. Treatment time for IA was two hours with a blood flow of 50 mL/min. A total plasma volume of 2.4 L was processed. Over the following days, creatinine declined, and the patient improved significantly. UPC decreased to 1.74 on day 17 after IA. The patient was discharged after two and a half weeks. Two years after the initial event, the patient is still in excellent condition, with creatinine, UPC, and albumin levels in the reference range. Therefore, IA might be an additional therapeutic option for dogs with leishmaniosis-induced glomerulonephritis and subsequent severe azotemia to improve immunocomplex-mediated glomerulonephritis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38535536/