Peer-reviewed veterinary case report
Protein in urine changes after leishmaniasis treatment in dogs
By Pierantozzi, Marco et al.·Published in Journal of the American Animal Hospital Association·2013·Clinica Veterinaria Pirani, Italy·View original on PubMed →
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Original publication title: Variation of proteinuria in dogs with leishmaniasis treated with meglumine antimoniate and allopurinol: a retrospective study.
- Species:
- dog
Plain-English summary
A group of 53 dogs diagnosed with leishmaniasis (a disease caused by parasites) were treated with two medications, meglumine antimoniate and allopurinol, for 4 to 8 weeks. Many of these dogs had protein in their urine, which can indicate kidney issues. After treatment, the levels of protein in the urine significantly decreased, and some dogs even returned to normal levels. This treatment not only helped reduce proteinuria (protein in urine) but also improved overall kidney function in many of the dogs.
People also search for: dog leishmaniasis treatment · protein in urine in dogs · allopurinol for dog kidney disease · dog kidney disease symptoms
Abstract
A retrospective study was performed using 53 client owned dogs with leishmaniasis to determine whether the degree of proteinuria, evaluated by the urine protein/creatinine ratio (UP/C), changes following treatment with meglumine antimoniate and allopurinol. Medical records of dogs with leishmaniasis in clinical stage C (according to the Canine Leishmaniasis Working Group staging system) and either proteinuric or borderline proteinuric (according to the International Renal Interest Society [IRIS] staging system) were reviewed. All dogs were treated with meglumine antimoniate and allopurinol for 4-8 wk. After treatment, UP/C, total protein, and total globulin significantly decreased and albumin and the albumin/globulin ratio (A/G) increased. After treatment, 7 of the 53 dogs (13.4%) became nonproteinuric following either a proteinuric or borderline proteinuric stage. Moreover, 12 of the 53 proteinuric dogs (22.6%) changed their stage to borderline proteinuric. The antileishmaniasis treatment with meglumine antimoniate in combination with allopurinol in dogs significantly reduced the degree of proteinuria in a short period of time. The results of the current study may be useful to the veterinary practitioner in the clinical management of canine leishmaniasis (CanL) in dogs with proteinuric chronic kidney disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23690493/