Peer-reviewed veterinary case report
Neurological problems in a 7-month Kooikerhondje after Bravecto dose
By Daniela Gaens et al.·Published in BMC Veterinary Research·2019·View original on Semantic Scholar →
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Original publication title: Suspected neurological toxicity after oral application of fluralaner (Bravecto®) in a Kooikerhondje dog
- Species:
- dog
Plain-English summary
A 7-month-old female Kooikerhondje was given Bravecto® for flea and tick prevention but developed neurological symptoms about 24 hours later. The dog showed signs like unsteady walking, muscle twitching, and difficulty swallowing. Fortunately, all these symptoms were temporary, and the dog fully recovered within 10 hours without any treatment. This case highlights that while Bravecto® is generally safe, some dogs may experience temporary neurological issues.
People also search for: Kooikerhondje neurological symptoms after Bravecto · dog tremors after flea treatment · Bravecto side effects in dogs
Abstract
BackgroundAlthough the new isoxazoline drug fluralaner (Bravecto®) is generally well tolerated in dogs, adverse drug reactions involving neurological dysfunction occurred in individual dogs. However, most of these cases are documented inadequately and none of them is reported and discussed in the literature. As isoxazoline drugs target neuronal chloride channels with a clear preference for invertebrates, they are considered to have a good safety profile. However, pharmacodynamic effects in the nervous system of vertebrates cannot be ruled out completely.Case presentationA seven-month-old female Kooikerhondje dog was treated with Bravecto® at the recommended dose. About 24 h after administration, the dog exhibited signs of neurological toxicity, including generalized ataxia, myoclonic jerks, tremor of head and body, muscle twitching and oral dysphagia. All symptoms were transient and the dog fully recovered without any treatment after 10 h.ConclusionThis case report describes transient occurrence of neurological dysfunction after administration of Bravecto®. It may help to better classify adverse drug reactions after application of isoxazoline drugs and documents a good prognosis even after occurrence of severe neurological dysfunction in the present case.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/31391054