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Peer-reviewed veterinary case report

Synergistic inhibition of the growth in vitro of Microsporum canis by miconazole and chlorhexidine.

Journal:
Veterinary dermatology
Year:
2003
Authors:
Perrins, N & Bond, R
Affiliation:
Department of Veterinary Clinical Sciences · United Kingdom

Plain-English summary

Researchers tested how well two antifungal treatments, miconazole and chlorhexidine, work against a fungus called Microsporum canis, which can cause skin infections in cats. They found that when these two medications were used together, they were more effective at stopping the growth of the fungus than when either was used alone. In fact, for most of the samples tested, the combination showed a strong effect, meaning they worked well together. This supports earlier findings that using both miconazole and chlorhexidine in a shampoo, along with another medication called griseofulvin, can be helpful in treating skin infections in cats caused by this fungus. Overall, the combination treatment appears to be a strong option for managing these infections.

Abstract

An agar dilution technique was used to assess the minimum inhibitory concentrations (MIC) of miconazole, chlorhexidine and a 1:1 combination of both agents for 10 isolates of Microsporum canis. For nine of 10 of the isolates, a combination of miconazole and chlorhexidine was more effective than either agent alone; fractional inhibitory concentration indices indicated a synergistic effect for five isolates and an additive effect for four. These results illustrate the potent antimycotic effect of miconazole and chlorhexidine against M. canis and are in accordance with previous clinical studies that showed the value of using miconazole and chlorhexidine shampoo in association with oral griseofulvin in the treatment of feline dermatophytosis caused by M. canis.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/12662267/