Peer-reviewed veterinary case report
Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2008
- Authors:
- Venu, T D et al.
- Affiliation:
- Department of Studies in Chemistry · India
Abstract
Reaction of 6a-f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a-f in excellent yield. The newly synthesized heterocycles were characterized by IR, (1)H NMR, and mass spectral data. Compounds 7a-f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18621525/