Peer-reviewed veterinary case report
Cat with T cell lymphoma and brain white matter damage
By Tsuboi, Masaya et al.·Published in The Journal of veterinary medical science·2010·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Systemic T cell large granular lymphocyte lymphoma with multifocal white matter degeneration in the brain of a Japanese domestic cat.
- Species:
- cat
Plain-English summary
A 10-year-old spayed female Japanese domestic cat showed signs of pancreatitis, which can cause vomiting and abdominal pain. A month later, she developed Horner's syndrome, a condition that affects the eyes and face, and was sadly euthanized. During the examination after her passing, veterinarians discovered multiple tumors in her intestines, spleen, kidneys, bladder, and lungs, indicating a diagnosis of large granular lymphocyte (LGL) lymphoma, a type of cancer. Unfortunately, the widespread nature of the cancer meant that treatment options were limited, and the cat's condition had progressed significantly by the time of diagnosis.
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Abstract
A 10-year-old spayed female Japanese domestic cat exhibited clinical symptoms suggesting pancreatitis. One month later the cat exhibited Horner's syndrome and was euthanized. At necropsy, multiple neoplastic masses were found in the intestines, spleen, kidneys, urinary bladder, and lungs. On cytology, many neoplastic lymphocytic cells had fine to large cytoplasmic granules, suggesting large granular lymphocyte (LGL) lymphoma. Histopathological examinations revealed infiltrative proliferation of the neoplastic cells in almost organs. Immunohistochemically, the neoplastic cells were intensely positive for CD3 and granzyme B. In the brain, there were multifocal white matter lesions characterized by diffuse myelin loss with mild infiltration of the neoplastic cells. Based on these findings, the cat was diagnosed as LGL lymphoma presumptively of intestinal origin with systemic involvement.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20124761/