Peer-reviewed veterinary case report
T-cell lymphoma causing rectal masses in a dog
By Hayes, Alison et al.·Published in Journal of comparative pathology·2023·Department of Veterinary Medicine, United Kingdom·View original on PubMed →
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Original publication title: T-cell lymphoma involving the rectum of a dog.
- Species:
- dog
Plain-English summary
A 7-year-old mixed breed dog was brought to the vet after showing signs of tiredness, not eating well, and having a fever for three weeks. Tests revealed she had advanced T-cell lymphoma affecting her mediastinum, liver, and spleen. Although she initially responded to chemotherapy, her condition worsened three months later, leading to vomiting, diarrhea, and painful bowel movements. A rectal exam showed multiple masses, and further tests confirmed the lymphoma had spread to her rectum. Unfortunately, rectal lymphoma is rare in dogs, and this case highlights its unusual presentation and progression.
People also search for: dog lymphoma symptoms · dog rectal mass treatment · mixed breed dog vomiting diarrhea
Abstract
A mediastinal mass was diagnosed in a 7-year-4-month-old neutered female mixed breed dog following a 3-week history of lethargy, hyporexia and pyrexia. Bi-cavitary imaging, needle aspirate cytology and flow cytometry confirmed WHO clinical stage IVb, intermediate to large T-cell lymphoma involving the mediastinum, liver and spleen. The dog initially responded to a multidrug chemotherapy protocol but clinical deterioration occurred 3 months later. The dog presented with anorexia, vomiting and diarrhoea, associated with marked faecal tenesmus and haematochezia, initially believed by the primary care practitioner to be related to chemotherapy toxicity. However, rectal examination revealed multiple sessile and pedunculated masses. Further diagnostic imaging, cytology and flow cytometry confirmed progressive disease, including T-cell lymphoma of the rectum. Histology and immunohistochemistry confirmed an infiltrate of intermediate-sized CD3-positive neoplastic cells that expanded the rectal mucosa. Rectal lymphoma is uncommon in dogs and previous cases have been B cell in origin. In this report we describe the clinical presentation and macro- and microscopic findings of a case of canine T-cell lymphoma involving the rectum.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37995445/