Peer-reviewed veterinary case report
Targeted Therapies in Veterinary Oncology.
- Journal:
- The Veterinary clinics of North America. Small animal practice
- Year:
- 2019
- Authors:
- Londhe, Priya et al.
- Affiliation:
- Tufts University School of Medicine · United States
Plain-English summary
Recent advances in understanding cancer at the molecular and genetic levels have led to new ways to treat it in pets. Researchers have identified specific proteins in cancer cells that can be targeted with small molecules, which work by blocking these proteins from doing their jobs. This approach has already been successful in treating various human cancers, with over 40 small molecule treatments approved. While this research is promising, it's still developing for pets, and more studies are needed to see how these therapies can be applied in veterinary medicine.
Abstract
Advances in molecular biology have permitted a much more detailed understanding of cellular dysfunction at the molecular and genetic levels in cancer cells. This has resulted in the identification of novel targets for therapeutic intervention, including proteins that regulate signal transduction, gene expression, and protein turnover. In many instances, small molecules are used to disrupt the function of these targets, often through competitive inhibition of ATP binding or the prevention of necessary protein-protein interactions. More than 40 small molecule inhibitors are now approved to treat a variety of human cancers, substantially impacting patient outcomes.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31186124/