Peer-reviewed veterinary case report
Tea polyphenols reduce liver inflammation in high fat-fed dogs
By Rahman, Sajid Ur et al.·Published in BMC veterinary research·2020·College of Animal Science and Technology, China·View original on PubMed →
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Original publication title: Tea polyphenols attenuate liver inflammation by modulating obesity-related genes and down-regulating COX-2 and iNOS expression in high fat-fed dogs.
- Species:
- dog
Plain-English summary
A group of dogs on a high-fat diet showed signs of liver inflammation, which can happen with obesity. When these dogs were given tea polyphenols, a natural compound found in tea, their liver inflammation improved significantly. The tea polyphenols helped reduce harmful substances in the liver and decreased fat content, leading to better overall liver health. This suggests that tea polyphenols could be a helpful treatment for dogs struggling with obesity and related liver issues.
People also search for: dog liver inflammation treatment · obesity in dogs · tea polyphenols for dogs · high-fat diet effects on dogs
Abstract
BACKGROUND: Tea polyphenols (TPs) attenuate obesity related liver inflammation; however, the anti-obesity effects and anti-inflammatory mechanisms are not clearly understood. This study aimed to determine whether the anti-obesity and anti-inflammatory TPs mechanisms associated with cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression levels, and obesity-related gene response in dogs. RESULTS: Dogs fed TPs displayed significantly decreased (p < 0.01) mRNA expression of tumor necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) compared to dogs that consumed high-fat diet (HFD) alone. TPs significantly (p < 0.01) inhibited COX-2 and iNOS expression level, and decreased liver fat content and degeneration. CONCLUSION: These results suggested that TPs act as a therapeutic agent for obesity, liver inflammation, and fat degeneration via COX-2 and iNOS inhibition, with TNF-α, IL-1β, and IL-6 involvement.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32641048/