Peer-reviewed veterinary case report
Inulin supplements reduce fat tissue inflammation in obese dogs
By Lu, Jiang et al.·Published in Research in veterinary science·2022·Department of Pet Science and Technology, China·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Dietary supplementation with low and high polymerization inulin ameliorates adipose tissue inflammation via the TLR4/NF-κB pathway mediated by gut microbiota disturbance in obese dogs.
- Species:
- dog
Plain-English summary
A group of obese dogs was given either low polymerization inulin (LPI) or high polymerization inulin (HPI) to see how it affected their inflammation and weight. The dogs receiving HPI showed a significant reduction in inflammation markers and fat accumulation compared to those on LPI. Both types of inulin improved gut health by changing the balance of gut bacteria, but HPI was more effective at reducing inflammation and improving obesity. This suggests that adding HPI to an obese dog's diet could help manage their weight and inflammation.
People also search for: dog obesity treatment · high polymerization inulin for dogs · how to reduce dog inflammation
Abstract
Inflammation induced by gut microbiota disorder plays an important role in promoting obesity. Inulin has beneficial effects on gut microflora and metabolic endotoxaemia. However, the chain length of inulin determines its different physiological effects. This study aimed to investigate the effect of low polymerization inulin (LPI) and high polymerization inulin (HPI) on inflammation in dogs with obesity induced by a high-fat diet and its potential mechanism. HPI, relative to LPI, significantly reduced the concentrations of LPS, IL-6 and TNF-α in serum and downregulated both the mRNA and protein expression of TLR4, NF-κB, TNF-α and IL-6 in adipose tissue. HPI and LPI intervention reduced adipose tissue fatty accumulation, which improved obesity. Supplementation with LPI and HPI increased gut microbiota diversity and altered specific bacterial populations at both the phylum and genus levels. The relative abundances of Prevotella, Fusobacterium and Enterobacter, which were positively correlated with the serum concentrations of LPS, IL-6 and TNF-α, were reduced. Our results demonstrate that both LPI and HPI can be used as an effective strategy for reducing inflammation and regulating gut microbiota, which can ameliorate obesity in dogs. Moreover, HPI exerts more positive regulation of the inflammatory response and gut microbiota dysfunction than LPI.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36208550/