Peer-reviewed veterinary case report
How terbinafine antifungal acts in dogs after one oral dose
By Sakai, Mary R et al.·Published in Veterinary dermatology·2011·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Terbinafine pharmacokinetics after single dose oral administration in the dog.
- Species:
- dog
Plain-English summary
Ten healthy adult dogs were given a single oral dose of terbinafine, an antifungal medication, to see how well it works in treating fungal infections. After the dose, blood samples were taken over 24 hours to monitor the drug's levels and any side effects. While most dogs tolerated the medication well, two experienced temporary eye changes. The study found that terbinafine stays in the dog's system long enough to effectively combat certain fungal infections. This suggests that terbinafine could be a useful treatment option for dogs with fungal infections.
People also search for: dog antifungal medication · terbinafine for dogs · dog eye changes after medication · treating fungal infections in dogs
Abstract
Terbinafine is an allylamine antifungal prescribed for the treatment of mycoses in humans. It is increasingly being used in veterinary patients. The purpose of this study was to evaluate the pharmacokinetic properties of terbinafine in dogs after a single oral dose. Ten healthy adult dogs were included in the study. A single dose of terbinafine (30-35 mg/kg) was administered orally, and blood samples were periodically collected over a 24 h period during which dogs were monitored for adverse effects. Two of 10 dogs developed transient ocular changes. A high-performance liquid chromatography assay was developed and used to determine plasma terbinafine concentrations. Pharmacokinetic analysis was performed using PK Solutions(®) computer software. Area under the curve (AUC) from time 0 to 24 h was 15.4 μg·h/mL (range 5-27), maximal plasma concentration (C(max) ) was 3.5 μg/mL (range 3-4.9 μg/mL) and time to C(max) (T(max) ) was 3.6 h (range 2-6 h). The time above minimal inhibitory concentration (T > MIC) as well as AUC/MIC was calculated for important invasive fungal pathogens and dermatophytes. The T > MIC was 17-18 h for Blastomyces dermatitidis, Histoplasma capsulatum and dermatophytes (Microsporum spp. and Trichophyton mentagrophytes), while the MIC for Sporothrix schenckii and Coccidioides immitis was exceeded for 9.5-11 h. The AUC/MIC values ranged from 9 to 13 μg h/mL for these fungi. Our results provide evidence supporting the use of terbinafine as an oral therapeutic agent for treating systemic and subcutaneous mycoses in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21599768/